| Qualifications and capacity: |
 |
Thomas Reinheckel (MD) studied medicine at the German Universities
in Magdeburg and Berlin
as well at the Albert-Einstein Medical College, N.Y., USA. During a 3 year internsip/residency Dr.
Reinheckel was trained in clinical management of gastrointestinal, pancreatic, and hepatocellular
carcinomas. Abroad pre- and postdoctoral training in biochemistry and tumour biology was at the
Albany Medical College and the UCSF
Cancer Center, San Francisco.
Since 2002 Dr. Reinheckel leads
the proteases group at
the Department of Molecular Medicine and Cell Research Freiburg and supervises
the core facility for generation of gene targeted mice at the Albert-Ludwigs-University
Freiburg, Germany.
|
| |
Christoph Peters (MD) is full professor of Molecular Medicine and
head of the Department of
Molecular Medicine and Cell Research Freiburg. Drs. Peters and Reinheckel are internationally
recognized for their pioneering studies using mouse molecular genetics to determine the biological
and pathological functions of cysteine cathepsins in vivo. By analysing several mouse models of
human cancer, this group has
gained a great expertise in the role of cathepsins in tumour
progression and formation of metastases.
|
|
|
Most relevant publications:
|
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice.
Vasiljeva, O., Korovin, M., Gajda, M., Brodoefel, H., Bojic, L., Krüger, A., Schurigt, U., Sevenich, L., Turk, B., Peters, C., Reinheckel, T.
Oncogene 27(30):4191-9 (2008)
|
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Halle, A., Hornung, V., Petzold, G.C., Stewart, C.R., Monks, B.G., Reinheckel, T., Fitzgerald, K.A., Latz, E., Moore, K.J., Golenbock, D.T.
Nat Immunol. 9(8):857-65 (2008)
|
Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart.
Spira, D., Stypmann, J., Tobin, D.J., Petermann, I., Mayer, C., Hagemann, S., Vasiljeva, O., Günther, T., Schüle, R., Peters, C., Reinheckel, T.
J. Biol. Chem. 282(51):37045-37052 (2007)
|
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
Vasiljeva, O., Papazoglou, A., Krüger, A., Brodoefel, H., Korovin, M., Deussing, J., Augustin, N., Nielsen, B.S., Almholt, K., Bogyo, M., Peters, C., Reinheckel, T.
Cancer Res. 66, 5242-5250 (2006)
|
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.
Petermann I, Mayer C, Stypmann J, Biniossek ML, Tobin DJ, Engelen MA, Dandekar T, Grune T, Schild L, Peters C and Reinheckel T
FASEB J, 20: 1266-1268, 2006
|
Distinct roles for cysteine cathepsin genes in multistage tumourigenesis.
Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D and Joyce JA
Genes Dev, 20: 543-556, 2006
|
Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM and Dimmeler S
Nat Med, 11: 206-213, 2005
|
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.
Stypmann J, Glaser K, Roth W, Tobin DJ, Petermann I, Matthias R, Monnig G, Haverkamp W, Breithardt G, Schmahl W, Peters C and Reinheckel T
Proc Natl Acad Sci USA, 99: 6234-6239, 2002
|
|
|
