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Dr. P. Barbry (PhD)
is the Director of The Institute of Molecular & Cellular Pharmacology
(IPMC, CNRS and University of Nice-Sophia-Antipolis), located in the High Technology Centre of
Sophia-Antipolis (110 scientists and 40 staff people organized in 16 autonomous teams) and the
coordinator of the French Transcriptome programme. With a strong background in physiology,
bioinformatics and transcriptome research, he has developed a unique bioinformatics and
Transcriptome facility producing public pangenomic or dedicated micro arrays.
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Dr. Bernard Mari (PhD)
is a Senior scientist in the group of "Physiological Genomics" directed
by Dr Pascal Barbry at IPMC. He leads the "lung
cancer and
microRNA"
group and has a strong background in
proteases-mediated cell activation,
cell signaling, apoptosis, tumour-stroma interaction,
microRNA and trancriptomic studies.
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K. Le Brigand (IR CNRS)
is bio-informatician and the main developer of Mediante project.
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K. Robbe (PstD)
is bio-informatician.
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CNRS grants access to microRNA
tools including a universal microRNA
microarray that is covering all known
microRNA in animals associated
with several bioinformatics tools dedicated for prediction of novel
microRNA and targets
identification (access).
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Most relevant publications:
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Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival.
Fromigue O, Louis K, Dayem M, Milanini J, Pages G, Tartare-Deckert S, Ponzio G, Hofman P, Barbry P, Auberger P and Mari B
Oncogene, 22: 8487-8497, 2003
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Tumour cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms.
Louis K, Guerineau N, Fromigue O, Defamie V, Collazos A, Anglard P, Shipp MA, Auberger P, Joubert D and Mari B
J Biol Chem, 280: 1272-1283, 2005
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An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes.
Le Brigand K, Russell R, Moreilhon C, Rouillard JM, Jost B, Amiot F, Magnone V, Bole-Feysot C, Rostagno P, Virolle V, Defamie V, Dessen P, Williams G, Lyons P, Rios G, Mari B, Gulari E, Kastner P, Gidrol X, Freeman TC and Barbry P
Nucleic Acids Res 34(12): e87, 2006
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Suppression of microRNA-silencing pathway by HIV-1 during virus replication.
Triboulet R, Mari B, Lin YL, Chable-Bessia C, Bennasser Y, Lebrigand K, Cardinaud B, Maurin T, Barbry P, Baillat V, Reynes J, Corbeau P, Jeang KT and Benkirane M
Science, 315: 1579-1582, 2007
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| miR-34b/miR-34c: a regulator of TCL1 expression in 11q- chronic lymphocytic leukaemia? |
| Leukemia. 2009 Nov;23(11):2174-7. | | Cardinaud B, Moreilhon C, Marcet B, Robbe-Sermesant K, Lebrigand K, Mari B, Eclache V, Cymbalista F, Raynaud S, Barbry P | | [1] CNRS, IPMC, UMR6097, Sophia Antipolis, France [2] Université de Nice Sophia-Antipolis, IPMC, UMR6097, Sophia Antipolis, France [3] Université Victor Segalen Bordeaux 2, EA 4135, Bordeaux, France E-mail: barbry@ipmc.cnrs.fr. |
| | Pubmed link : 19536169 |
| Mediante: a Web-based Microarray Data manager |
| Bioinformatics, doi:10.1093/bioinformatics/btm106 | | Le Brigand K, Barbry P | | CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097, 660, route des Lucioles, F-06560 Sophia Antipolis, France. |
Summary : Mediante is a MIAME-compliant microarray data manager that links together annotations and experimental data. Developed as a J2EE three-tier application, Mediante integrates a management system for production of long oligonucleotide microarrays, an experimental data repository suitable for home made or commercial microarrays, and a user interface dedicated to the management of microarrays projects. Several tools allow quality control of hybridizations and submission of validated data to public repositories.
Availability : http://www.microarray.fr.
Supplementary data : http://www.microarray.fr/SP/lebrigand2007/ | | Pubmed link : 16855282 |
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