| Qualifications and capacity: |
Carlos Lopez-Otin (PhD) is a Professor of Biochemistry and Molecular Biology. His group
has identified and characterized more than 60 novel human proteolytic enzymes, most of them
isolated as a consequence of their overexpression in malignant tumours. His group has also
generated animal models involving either gain or loss of
protease function
for the functional study of these enzymes.
He has introduced the novel concept of Degradome to define the complete
set of proteases
produced by a cell, tissue or organism, and belongs to the international
consortia created for the sequencing and analysis of diverse mammalian genomes.
Xose S. Puente (PhD) is a "Ramon y Cajal" Research Associate at Universidad de Oviedo.
He has a strong background in Cell Biology and Bioinformatics. He has a long experience in
the study of the relevance of the microenvironment in tumour progression. He has been directly
involved in the definition of the complexity of proteolytic systems operating in human cells
and has designed new tools to address the global analysis of
proteases associated
with cancer
invasion and metastasis.
Jose M.P. Freije (PhD) is an Associate Professor of Biochemistry and Molecular Biology
at Universidad de Oviedo. He is an expert in the generation of genetically modified mice.
Gloria Velasco (PhD) is an Associate Professor of Biochemistry at Universidad de Oviedo
and an expert in the enzymatic analysis of
proteases of relevance in cancer.
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Most relevant publications:
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Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase deficient mice.
Pendás A, Zhou Z, Cadiñanos J, Freije JP, Wang J, Hultenby K, Astudillo A, Wernerson A, Tryggvason K and López-Otín C
Nature Genetics, 31: 94-99, 2002
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Loss of collagenase-2 confers increased skin tumour susceptibility to male mice.
Balbín M, Fueyo A, Tester A, Pendás A, Pitiot A, Astudillo A, Overall C, Shapiro S and López-Otín C
Nature Genetics, 35: 252-257, 2003
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Genome sequence of the brown Norway Rat yields insights into mammalian evolution.
Rat Genome Sequencing Project Consortium (including XS Puente & C López-Otín /Univ. Oviedo, Spain)
Nature, 428: 493-521, 2004
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Initial sequence of the chimpanzee genome and comparison with the human genome.
The Chimpanzee Sequencing and Analysis Consortium (including XS Puente, G Velasco and C López-Otín - Univ. Oviedo, Spain)
Nature, 437: 69-87, 2005
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Accelerated aging in mice deficient in Zmpste24 protease is linked to p53 signaling activation.
Varela I, Cadiñanos J, Pendás A, Gutiérrez-Fernández A, Folgueras A, Sánchez L, Zhou Z, Rodríguez F, Stewart C, Vega J, Tryggvason K, Freije J and López-Otín C
Nature, 437:564-568, 2005
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