| Qualifications and capacity: |
Paolo Comoglio graduated in Medicine at the University of Torino in 1969.
He then studied Immunology with Herman Eisen at the Washington University in
Saint Louis and, in 1973, studied the biological properties of neoplastic cells
with Leonard Warren at the University of Pennsylvania in Philadelphia. Returning
to Italy in 1974 he became Associate Professor and then, in 1980, Full Professor of
Histology at the University of Trieste Medical School. In 1983 he took on a position
as Full Professor of Histology at the University of Torino Medical School. He has been
Director of the Division of Molecular Oncology at the Institute for
Cancer Research and
Treatment (IRCC) in Candiolo (Torino) since 1996. He was then appointed IRCC Scientific
Director in January 2000.
Carla Boccaccio (MD) is Associate Professor at the Department of Oncological Sciences,
University of Torino and group leader in the Division of Molecular Oncology, at the Institute
for Cancer
Research and Treatment (IRCC), Candiolo (Torino). She has been studying the invasive
growth signalling pathways and genetic program for many years. She recently developed in vivo
models of invasive growth and the investigation of MET expression and function in
(cancer) stem cells.
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| Most relevant publications: |
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M and Comoglio PM.
Cell, 99: 71-80, 1999
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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
Trusolino L, Bertotti A and Comoglio PM.
Cell, 107:643-54, 2001.
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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.
Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S and Comoglio PM.
Cancer Cell, 4: 347-361, 2003
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Tarteting the tumour and its microenvironment by a dual-function decoy Met receptor.
Michieli P, Mazzone M, Basilico C, Cavassa S, Sottile A, Naldini L and Comoglio PM.
Cancer Cell, 6: 61-73, 2004
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The MET oncogene drives a genetic programme linking cancer to haemostasis.
Boccaccio C, Sabatino G, Medico E, Girolami F, Follenzi A, Reato G, Sottile A, Naldini L and Comoglio PM
Nature, 434: 396-400, 2005
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